Liver extract refractory megaloblastic anemia.

Megaloblastic anemia probably caused by defective utilization of folinic acid.

By FARm 1. FIAuRANI, GEORGE WANG AND L. M. T0cANrINs I HE COMMON types of megaloblastic anemias usually res1)ond well to vitamin B-12 or folic acid but there are some which respond incompletely or not at all to these antianemic agents. In 1936, Israel and \Vilkinson referred to these megaloblastic anemias which are refractory to liver extract as “Achrestic n1 ‘ Since then a number of cases have...

Refractory megaloblastic anemia.

Refractory pancytopenia and megaloblastic anemia due to falciparum malaria.

Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria. We present a case with refractory megaloblastic anemia with asymptomatic falciparum malaria. We hypothesize that promoter variants in the inducible nitric oxide synthase gene might be the cause of severe refractory megaloblastic anem...

Megaloblastic Anemia in Pregnancy

MegalobJastic Anemia in Pregnancy Megaloblastic Anemia is one of The Rather Common Diseases of Pregnant Women Caused by Folic acid Defi­ciency The Disease Might Be Hazardous To affected Mo­thers and also Could be Fatal for foetus too.  Megaloblastic Pregnant Women Will have Signs and Symptoms of This Disease mostly after 29th. Week of pregnancy.  Adequate amount of Folate Will prevent Compli...

Refractory megaloblastic anemia associated with excretion of orotic acid.

By CiIAnLI s M. HUGULEY, Jn., JAMES A. BAIN, SHIRLEY L. RIVERS AND ROBERT B. ScoGcINs T HE MAJORITY of anemias associated with a megalohiastic hone marrow respond to vitamin B,2 parenterally. Those which do not respond usually fall into well defined categories of nutritional deficiency, intestinal malahsorption syndromes, pernicious anemia of pregnancy, megaloblastic anemia of infancy or reacti...